15 years of scientific researches

in biotechnologies, tested and validated in hospitals

The research into probiotic cleaning for hospitals was primarily driven by the significant drawbacks of conventional chemical disinfection and the escalating public health crisis posed by healthcare-associated infections (HAIs) and multi-drug resistant organisms (MDROs).

• Critical Problem of Pathogen Transmission and Antimicrobial Resistance (AMR):

  • Contaminated environmental surfaces are a major source of HAIs, which affect approximately 15% of hospitalized patients globally.

  • Pathogens, including MDROs like MRSA and Clostridium difficile, can survive on surfaces for extended periods.

  • Increasing drug resistance further complicates HAIs, necessitating new approaches to reduce transmission.

• Limitations of Conventional Chemical Disinfection:

  • Chemical disinfectants offer only short-term pathogen abatement and fail to prevent rapid recontamination.

  • Continuous use can select for resistant microbial strains and potentially stimulate cross-resistance to antibiotics.

  • These methods carry a high environmental impact and pose risks to humans (e.g., cleaning staff safety).

Faced with these challenges, researchers sought an efficient, low-impact, and long-lasting alternative, leading to the development of probiotic cleaning based on a biocontrol concept.

• Introduction of the Biocontrol Concept:

  • The core idea shifted from eradicating all microbes to replacing "bad" microbes with "good" ones.

  • This ecological approach utilizes the principle of biological competition or competitive exclusion.

  • By colonizing surfaces with beneficial probiotic bacteria, the aim is to establish a long-term stable microbiome, thereby reducing the risk of infection by outcompeting nosocomial pathogens.